Facts have proved that high blood pressure if left untreated, can lead to serious cardiovascular diseases and kidney disease, mortality and disability will be greatly increased. This shows that China’s prevention and treatment of high blood pressure situation is very serious. To this end, experts on how to effectively prevent and control high blood pressure conducted in-depth study and have come to the following three important conclusions:

1, systolic blood pressure is more dangerous than elevated diastolic blood pressure

The last century 70’s, people think, with the systolic blood pressure increase were higher age, which is a “natural phenomenon”, thus the increase of systolic blood pressure for no special attention, and that the increase of diastolic blood pressure of the incidence of patients with cardio-cerebral vascular diseases have a greater impact. By the late 80s, through a large number of clinical studies, people come to believe that the increase of systolic and diastolic blood pressure the harm to the human body are similar.

Into the 21st century, a number of large-scale evidence-based medicine research changed the way people view the past that the systolic blood pressure can lead to cardio-cerebral vascular diseases more dangerous factor; systolic blood pressure rise, and could allow patients suffering from coronary heart disease 1.5 ~ 1.6-fold increased risk, can increase the risk of stroke in patients suffering from 1.8 to 2,6 times, can increase the risk of heart failure in patients suffering from 1.5 to 2 times that in patients suffering from peripheral vascular disease can increase the risk of 1.8 ~ 2.1 times: the higher the systolic blood pressure, heart and brain disease patients in the greater the risk. Because of this, people have elevated systolic blood pressure should attention.

2, combination therapy better than single medications

The earlier view, treatment of hypertension should focus on starting a drug used alone, when such a treatment is unsatisfactory, the first to consider increasing the dose of drugs rather than increasing the variety of drugs. Diagnosis and treatment of high blood pressure assessment committee of the United Nations has to diuretics, β blockers, angiotensin-converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB) and α-blockers as a single used first-line antihypertensive drugs recommended to States for the public.

The latest view is that the majority of hypertensive patients should choose combination therapy. A number of studies showed that patients with a single medication than patients on combination therapy with low rates of hypertension control, adverse reactions and more, and easily so that patients give rise to dose-dependent. Single agent can only provide 40% or less blood pressure in hypertensive patients to achieve compliance, while the combination therapy in patients with hypertension the blood pressure can increase to 80% compliance rate of more than a single medication compliance rate should be twice as high. Combination therapy can be fully reflects the mechanism of the different types of anti-hypertensive drugs, the advantages of better play their role in blood pressure together, increase the stability of blood pressure and reducing adverse drug reactions, and can achieve good blood pressure lowering effect of .

In 2003 the United States a report on the prevention and treatment of high blood pressure (JNC7) made: In order to achieve the target blood pressure in patients with hypertension level (ie, 140/90 mm Hg), the majority of hypertensive patients need to take two or more of the antihypertensive drug treatment: If the patient’s actual blood pressure, high blood pressure than the standard 20/10 mm Hg, and its initial treatment should be used two kinds of antihypertensive drugs, one of which should be a thiazide diuretic. In 2003 Europe’s “high blood pressure Guide” points out: Diuretics fit and most other types of antihypertensive drugs used in combination. Small doses of thiazide diuretics can significantly enhance the angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, α blockers, β blockers and vasodilator antihypertensive effect. The use of low-dose hydrochlorothiazide in patients with hypertension will enable 50% of the decline in blood pressure, and do not cause patients with metabolic disorders.

3, angiotensin receptor blocker plus a small dose of diuretic to reduce systolic blood pressure had an obvious advantage

Studies have shown that in many antihypertensive drugs, the effect of losartan and other angiotensin receptor blockers on stroke prevention and treatment more effective. In the hypertension associated with left ventricular hypertrophy and atrial fibrillation in patients with a history of the use of losartan treatment can reduce their risk of stroke incidence of 45%, the risk of death can be reduced to 42%. Have occurred in patients with stroke, the use of losartan in patients treated with the use of other antihypertensive drugs than patients treated suffered nerve damage to be much lighter.

From the effects of antihypertensive drugs, adverse reaction, dependency on the disease control rate and other considerations, the antihypertensive effect of a good selection of the fixed compound preparations for treatment of high blood pressure have a greater advantage. In which angiotensin receptor blockers plus low-dose diuretics have been widely used in clinical, it can effectively reduce systolic blood pressure, the treatment of hypertensive patients with atrial fibrillation, left ventricular hypertrophy and stroke in patients with a unique advantage.