Fatty liver can cure early — the rule governing
Posted on November 16th, 2009 in liver | Comments Off
Fatty liver in accordance with its development process, typically starting from a simple fatty liver, and gradually develop into steatohepatitis, liver fibrosis and cirrhosis.
1. Simple fatty liver can be fully recovered in time rule
Simple fatty liver is a fatty liver in the initial stages. Due to unhealthy eating and lifestyle habits (eating more, moving less), alcohol, drugs and chemical poisons and other damage, resulting in liver appeared abnormal lipid metabolism, fat accumulation in liver cells began.
Simple fatty liver may be no clinical manifestations, easy to overlook patients, some patients can be expressed as a sense of fatigue, poor appetite, nausea, bad breath, abdominal distension, constipation and so on, through the B extra fine examination can be found. Some patients showed these symptoms can be aggravated liver discomfort or pain, etc. can also be accompanied by diabetes, hyperlipemia, hypertension, coronary heart disease, cerebral vascular disease.
Simple fatty liver stage of liver cell damage has not yet appeared, liver function, and transaminases are all completely normal. This is the best prevention and treatment of fatty liver stage, but also the most easily overlooked dangerous level, and if early detection, timely treatment, can be completely back to normal.
Treatment is relatively simple. First of all, to change the bad habits of treatment is all about. This period most patients with fatty liver can lose weight, quit drinking, control of fat intake, avoid exposure to hazardous substances to the liver and other channels to “slim down” so that the liver completely back to normal. If it is, or transhepatic imaging examination that the more severe cases of fatty liver can be remedied with medication, such as the need to add the liver metabolism of vitamin C, vitamin E, oral polyene phosphatidyl choline, milk thistle, bicyclic alcohol drugs such as protecting the liver cell membrane. If the patient body mass index, blood pressure, waist circumference, blood glucose, blood lipids and other indicators to judge belonging to the metabolic syndrome or metabolic syndrome, high-risk groups, it should also be timely and drugs such as metformin increase the body’s insulin sensitivity, islet cells to ease the “work pressure “, delay or eliminate the occurrence of metabolic syndrome.
Simple fatty liver in the comprehensive treatment, Liver drug is a complementary therapeutic measures, is a short-term intensive behavior; require a high degree of attention and adjustment of patients with long-term, is the patient’s diet, exercise, and bad behavior amendments. These non-drug treatment measures need to be followed for life, or fatty liver disease is cured, they would relapse.
2. Fat hepatitis after treatment the majority of recoverable
Fat is a simple fatty liver hepatitis has not been well controlled, a further increase in liver fat accumulation, resulting in the beginning part of the destruction of liver cells, liver function are affected, transaminases began to rise stage. Although this time of fatty liver has been gradually revealing ugly, but patients are often only mild symptoms. This is also the risk of fatty liver in one of the reasons.
With other liver diseases caused by elevated aminotransferase is different from that of non-alcoholic steatohepatitis (NAFLD) in patients with elevated aminotransferases are usually mild, long duration, usually no clinical symptoms.
Non-alcoholic fatty liver disease is a progressive liver disease. Found in the initial liver biopsy of liver fibrosis and liver cirrhosis of the liver iron content in excess is a harbinger of the two independent risk factors, and liver fibrosis is apparent or the bridge-like fibrosis, NASH rapidly progressed to cirrhosis of the liver sign. Age ≥ 45 years of age, body mass index (BMI) ≥ 30kg/m2, AST / ALT ratio of “1, and at intervals of type 2 diabetes risk factors of fibrosis or cirrhosis. Fatty cirrhosis of liver lipid droplets and inflammatory cells and sometimes completely receded, and NASH is an important cause of cryptogenic cirrhosis.
At this stage, the basis of treatment with simple fatty liver or less the same and correct any improper diet and living habits are still very important. In addition, Liver drug adjuvant therapy is very important. Although the fat-type hepatitis after treatment of the correct specification can also be returned to normal, but compared to the treatment of simple fatty liver is much more difficult, you may need six months or even longer treatment, but older, poorer physical basis for the recovery The more slowly.
3. The treatment of liver fibrosis and cirrhosis of the liver to grasp the good opportunity to
Recent studies found that under the action of various risk factors, fatty liver and cirrhosis of the liver often have occurred or in combination, so fatty liver and liver fibrosis and cirrhosis of the relationship and its mechanism, more aroused great attention and in-depth research.
The type of fatty liver and liver fibrosis is closely related to, according to the size of lipid droplets within the liver cells is different from pathological into large bubbles and small bubbles fatty liver fatty liver; macrovesicular fatty liver and liver fibrosis and cirrhosis close. Macrovesicular fatty liver disease because of differences arising from the liver fibrosis, cirrhosis of the probability and the process is also different. Clinically classified according to their cause of alcoholic and non-alcoholic fatty liver in two categories, the latter mainly by obesity, diabetes, hyperlipoproteinemia, drug, poison, and malnutrition due.
Simple fatty liver is also the early stage of cirrhosis of the liver lesions is not, as past of the view that the non-alcoholic fatty liver disease as benign lesions, do not develop hepatic fibrosis and cirrhosis of the liver. But non-alcoholic fatty liver disease must be on the basis of steatohepatitis will develop liver fibrosis and cirrhosis. Non-alcoholic steatohepatitis pathological changes similar to alcoholic hepatitis, alcoholic hepatitis, but compared to a lesser extent, progress has been slower, a lower incidence of cirrhosis of the liver. Long-term large doses of estrogen, an iodine ketones drugs and small intestinal bypass surgery caused by non-alcoholic fatty liver in liver fibrosis and cirrhosis more likely than diabetes, obesity caused by those who for these purposes.
It is considered anti-fibrosis therapy should be advanced to and treatment of primary disease at the same time, or until after the formation of hepatic fibrosis has been promoting its absorption or degradation is rather difficult. Currently considered its treatment can be divided into several steps: removal of incentives to reduce liver inflammation; interfere with the production of extracellular matrix; increase in extracellular matrix degradation; inhibit hepatic stellate cell activation and proliferation; improve liver cell function, increased hepatic cells.