Archive for the ‘liver’ Category

With the new strategy for treating cirrhosis of the liver

Posted on January 25th, 2010 in liver | 1 Comment »

Why is cirrhosis of the liver treatment bad?

Cirrhosis of the liver is a clinical common and frequently-occurring disease, the disease had entered the progressive development of decompensated period, could eventually lead to liver failure. The digestive system of common diseases, but also serious consequences of the disease, the annual incidence of 17 hundred thousandths, mainly involving 20 to 50 year-old male. Urban males 50 to 60-year-old patients with cirrhosis of the case-fatality rate of up to 112 hundred thousandths.

In May 2005 held in Beijing, “Chinese Medical Association, the Twelfth National Conference on Viral Hepatitis and Liver Disease,” on the well-known experts in the topics mentioned in the report, the current 20% to 30% of cirrhosis of the liver can be developed for the loss of decompensated cirrhosis; 6% to 15% may develop hepatocellular carcinoma. The 5-year survival rate: 55% compensated cirrhosis, decompensated liver cirrhosis was 14%, die each year from hepatitis B-related liver disease and 30 million to 50 万 人.

For the treatment of disease, at present the main clinical symptomatic liver protection and prevention of complications is still mainly dissatisfied with the overall treatment effect, particularly in the treatment of end-stage liver disease overall effectiveness of even worse.

Liver transplantation is the only way out?

China is a big country liver disease alone, there are tens of millions of hepatitis B patients, in a large number of end-stage liver disease in liver transplant recipients are also required every year hundreds of thousands. In recent years, orthotopic liver transplantation Although end-stage liver disease as the best treatment options, but because of the shortage of donor liver and postoperative adverse events are more life-long need to take immunosuppressive drugs and high medical costs limit their clinical applications, in the clinical treatment has not been satisfactory progress.

Acute liver failure occurs when the short-term appeared in a sharp deterioration in liver function, leading to progressive altered mental status, coagulation dysfunction, infections, renal failure. In liver transplant technology to promote the former, their survival rate less than 15%, while the implementation of liver transplantation, one-year survival rate of nearly 80%. Liver failure is extremely high mortality syndrome, a serious liver disease. Like with liver cirrhosis, liver transplantation for treatment of advanced liver failure, although the most effective means, but because of medical ethics, transplant donor, transplant rejection, treatment costs and other constraints, it is difficult to carry out a wide range.

Stem cells bring new hope in recent years, molecular biology and cell bio-engineering technology, as well as in-depth understanding of stem cell research through stem cell transplantation for treatment of end-stage liver disease is becoming a hot research, which for end-stage liver diseases, in particular, is the terminal decompensated cirrhosis and acute liver failure treatment offers a new strategy.

A large number of clinical and preclinical studies have shown that directed differentiation of bone marrow stem cells have the proliferative capacity of the environment in the liver to be able to differentiate into liver cells, can participate in repair and reconstruction of the liver structure and improve liver function. For liver stem cell transplantation in the treatment of liver diseases can play an important role.

Studies have shown that the liver stem cells and regeneration requires the participation of cytokines. How to control stem cell differentiation and development, it differentiated into liver cells do? Experts believe that, depending on the survival of transplanted cells and the combined effects of micro-environment in which stem cells may play an important role in survival of micro-environment. From the current study, as long as the micro-environment for liver regeneration, stem cells can differentiate into hepatocytes in vivo.

How to make liver damage "renewable"?

Posted on November 16th, 2009 in liver | 1 Comment »

According to WHO statistics, there are around more than 350 million people are infected with chronic hepatitis B. Studies have shown that the highest levels of viral load of hepatitis B patients eventually developed cirrhosis and liver cancer risk increased significantly. With the rapid development of medicine, the treatment of chronic hepatitis B patients getting better and better prospects for a few days ago, the United States Institute announced the world’s first liver-specific progressed to decompensated cirrhosis, chronic hepatitis B patients with antiviral therapy and security studies, and once again recommends Baraclude (entecavir tablets) for long-term treatment of chronic hepatitis B patients with the best choice.

■ 80% of primary liver cancer and hepatitis B virus infection

The liver function is essential for human life. As the largest solid organ in the body, the liver has more than 500 kinds of features, including the fight against infection and disease, controlling cholesterol generation and discharge, clear the blood of waste, drugs and other toxic substances.

According to statistics, every year about one million patients with hepatitis B because it has not received medical treatment. Hepatitis B through blood and other body fluids to spread, such as semen, vaginal secretions, saliva, sores, as well as milk. 90% of the population can be formed within a few months hepatitis B virus (HBV) immunity and clear the virus, but some people can not. These people become carriers of the virus and may develop into chronic hepatitis. The first cause of chronic hepatitis B liver infections, leading to healthy liver cell damage, scar tissue formation, damage to liver function. Most patients with hepatitis B do not show any symptoms, so some persons infected with chronic hepatitis B virus infection after many years were ignorant.

Suffering from cirrhosis of the liver with chronic hepatitis B infection and liver cancer risk is higher. On a global scale, up to 80% of primary liver cancer (almost always be fatal) and the hepatitis B virus infection. Hepatitis B virus liver disease and of liver cancer is the world’s leading cause of death.

■ liver decompensation is very slim hope of cure

5% -7% each year with hepatitis B virus-related cirrhosis of the liver from compensatory to decompensated. Once the liver decompensation, cure would like to rather slim. Severe liver injury, including the impact of weight loss, fatigue, weakness, increased risk of severe bleeding, most patients will die of liver decompensation. Hepatic decompensation in patients with an average survival period of two years, the survival period of five years, the percentage of patients with only 28%.

Symptoms of liver decompensation include:

Jaundice (yellowing of skin or sclera)

Ascites (abnormal accumulation of water caused by abdominal distension)

Esophageal varicose veins (varicose blood vessels may result in potentially fatal bleeding)

Hepatic encephalopathy (neuropsychiatric abnormalities caused by personality changes, intellectual decline, confusion)

■ potent and lasting viral suppression is a delay or reverse the underlying disease progression of hepatitis B

In view of the progress of chronic hepatitis B-related disease on patients the health effects of China’s “Guide to prevention and treatment of chronic hepatitis B,” it clear that the overall goal of the treatment of chronic hepatitis B is: as much as possible long-term suppression or elimination of hepatitis B virus, reducing inflammation and necrosis of liver cells, and liver fibrosis, delay and prevent disease progression, reduce and prevent liver decompensation, liver cirrhosis, liver cancer and its complications, thereby improving the quality of life and extend survival time.

Disease progression of chronic hepatitis B, mainly due to hepatitis B virus infection caused by chronic inflammation caused by, but the current medical standards not yet completely clear the body of the hepatitis B virus. Therefore, potent and sustained suppression of hepatitis B virus, which is to improve the liver tissue, and then slow down or even reverse the disease progression of hepatitis B lies.

Numerous studies confirmed that the powerful and lasting viral suppression, which would enable the vast majority of patients with chronic hepatitis B under control, curb disease, cirrhosis or liver cancer to develop in the direction; the other hand, can help patients with disease progression has occurred, to reduce inflammation, improve or even reverse fibrosis and improve patient survival.

At the 60th AASLD Annual Meeting to the latest clinical trial research shows that people with decompensated liver cirrhosis, chronic hepatitis B patients receive long-term Baraclude (entecavir tablets) treatment, not only has a good safety and tolerance, but also significantly reduce the viral load and improve the clinical indicators of liver function. The published studies, is the world’s first specifically progressed to decompensated cirrhosis, chronic hepatitis B patients, to assess its anti-virus treatment efficacy and safety study.

■ prevention of drug-resistant, so powerful and lasting viral suppression is possible

The progress of chronic hepatitis B and its related diseases in the anti-viral treatment, it is also faced with resistance to the biggest “stumbling block.” In the treatment of drug resistance could occur at any stage. The event of resistance, the virus re-active replication, causing disease progression, so that antiviral therapy come to naught. Due to the presence of cross-resistance in case of resistance, but also limits the choice of treatment in patients with follow-up.

Therefore, many parts of the world’s hepatitis B treatment guidelines have pointed out that the progress of hepatitis B and related diseases in patients with antiviral therapy should be to prevent drug resistance, the preferred high genetic barrier, low resistance rates of drugs. Therefore, patients with hepatitis B should be taken to prevent drug resistance strategies, emphasis on the initial treatment of choice from the outset, powerful anti-virus and a high barrier of drug resistance genes in order to achieve long-term stability of hepatitis B disease control and continuously improve their own lives quality.

Fatty liver can cure early — the rule governing

Posted on November 16th, 2009 in liver | No Comments »

Many people in the health examination, identified fatty liver. Because of these people have no symptoms, so mistakenly believe that fatty liver is not a disease. In fact, fatty liver is not only a disease, but also because of its hidden nature, it is easy to miss the best time for treatment and worse.

Fatty liver in accordance with its development process, typically starting from a simple fatty liver, and gradually develop into steatohepatitis, liver fibrosis and cirrhosis.

1. Simple fatty liver can be fully recovered in time rule

Simple fatty liver is a fatty liver in the initial stages. Due to unhealthy eating and lifestyle habits (eating more, moving less), alcohol, drugs and chemical poisons and other damage, resulting in liver appeared abnormal lipid metabolism, fat accumulation in liver cells began.

Simple fatty liver may be no clinical manifestations, easy to overlook patients, some patients can be expressed as a sense of fatigue, poor appetite, nausea, bad breath, abdominal distension, constipation and so on, through the B extra fine examination can be found. Some patients showed these symptoms can be aggravated liver discomfort or pain, etc. can also be accompanied by diabetes, hyperlipemia, hypertension, coronary heart disease, cerebral vascular disease.

Simple fatty liver stage of liver cell damage has not yet appeared, liver function, and transaminases are all completely normal. This is the best prevention and treatment of fatty liver stage, but also the most easily overlooked dangerous level, and if early detection, timely treatment, can be completely back to normal.

Treatment is relatively simple. First of all, to change the bad habits of treatment is all about. This period most patients with fatty liver can lose weight, quit drinking, control of fat intake, avoid exposure to hazardous substances to the liver and other channels to “slim down” so that the liver completely back to normal. If it is, or transhepatic imaging examination that the more severe cases of fatty liver can be remedied with medication, such as the need to add the liver metabolism of vitamin C, vitamin E, oral polyene phosphatidyl choline, milk thistle, bicyclic alcohol drugs such as protecting the liver cell membrane. If the patient body mass index, blood pressure, waist circumference, blood glucose, blood lipids and other indicators to judge belonging to the metabolic syndrome or metabolic syndrome, high-risk groups, it should also be timely and drugs such as metformin increase the body’s insulin sensitivity, islet cells to ease the “work pressure “, delay or eliminate the occurrence of metabolic syndrome.

Simple fatty liver in the comprehensive treatment, Liver drug is a complementary therapeutic measures, is a short-term intensive behavior; require a high degree of attention and adjustment of patients with long-term, is the patient’s diet, exercise, and bad behavior amendments. These non-drug treatment measures need to be followed for life, or fatty liver disease is cured, they would relapse.

2. Fat hepatitis after treatment the majority of recoverable

Fat is a simple fatty liver hepatitis has not been well controlled, a further increase in liver fat accumulation, resulting in the beginning part of the destruction of liver cells, liver function are affected, transaminases began to rise stage. Although this time of fatty liver has been gradually revealing ugly, but patients are often only mild symptoms. This is also the risk of fatty liver in one of the reasons.

With other liver diseases caused by elevated aminotransferase is different from that of non-alcoholic steatohepatitis (NAFLD) in patients with elevated aminotransferases are usually mild, long duration, usually no clinical symptoms.

Non-alcoholic fatty liver disease is a progressive liver disease. Found in the initial liver biopsy of liver fibrosis and liver cirrhosis of the liver iron content in excess is a harbinger of the two independent risk factors, and liver fibrosis is apparent or the bridge-like fibrosis, NASH rapidly progressed to cirrhosis of the liver sign. Age ≥ 45 years of age, body mass index (BMI) ≥ 30kg/m2, AST / ALT ratio of “1, and at intervals of type 2 diabetes risk factors of fibrosis or cirrhosis. Fatty cirrhosis of liver lipid droplets and inflammatory cells and sometimes completely receded, and NASH is an important cause of cryptogenic cirrhosis.

At this stage, the basis of treatment with simple fatty liver or less the same and correct any improper diet and living habits are still very important. In addition, Liver drug adjuvant therapy is very important. Although the fat-type hepatitis after treatment of the correct specification can also be returned to normal, but compared to the treatment of simple fatty liver is much more difficult, you may need six months or even longer treatment, but older, poorer physical basis for the recovery The more slowly.

3. The treatment of liver fibrosis and cirrhosis of the liver to grasp the good opportunity to

Recent studies found that under the action of various risk factors, fatty liver and cirrhosis of the liver often have occurred or in combination, so fatty liver and liver fibrosis and cirrhosis of the relationship and its mechanism, more aroused great attention and in-depth research.

The type of fatty liver and liver fibrosis is closely related to, according to the size of lipid droplets within the liver cells is different from pathological into large bubbles and small bubbles fatty liver fatty liver; macrovesicular fatty liver and liver fibrosis and cirrhosis close. Macrovesicular fatty liver disease because of differences arising from the liver fibrosis, cirrhosis of the probability and the process is also different. Clinically classified according to their cause of alcoholic and non-alcoholic fatty liver in two categories, the latter mainly by obesity, diabetes, hyperlipoproteinemia, drug, poison, and malnutrition due.

Simple fatty liver is also the early stage of cirrhosis of the liver lesions is not, as past of the view that the non-alcoholic fatty liver disease as benign lesions, do not develop hepatic fibrosis and cirrhosis of the liver. But non-alcoholic fatty liver disease must be on the basis of steatohepatitis will develop liver fibrosis and cirrhosis. Non-alcoholic steatohepatitis pathological changes similar to alcoholic hepatitis, alcoholic hepatitis, but compared to a lesser extent, progress has been slower, a lower incidence of cirrhosis of the liver. Long-term large doses of estrogen, an iodine ketones drugs and small intestinal bypass surgery caused by non-alcoholic fatty liver in liver fibrosis and cirrhosis more likely than diabetes, obesity caused by those who for these purposes.

It is considered anti-fibrosis therapy should be advanced to and treatment of primary disease at the same time, or until after the formation of hepatic fibrosis has been promoting its absorption or degradation is rather difficult. Currently considered its treatment can be divided into several steps: removal of incentives to reduce liver inflammation; interfere with the production of extracellular matrix; increase in extracellular matrix degradation; inhibit hepatic stellate cell activation and proliferation; improve liver cell function, increased hepatic cells.

How the prevalence of hepatitis B liver protection?

Posted on November 4th, 2009 in liver | No Comments »

China is a big country, but also a hepatitis B power. For hepatitis B patients, disease, torture is not only confined to the physical, social discrimination but also gives them the physical and psychological harm.

They suffer in silence without going through standard treatment, many patients with advanced cirrhosis of the liver into the period of serious complications, and even the development of liver cancer, resulting in early death. In this regard, a press interview with liver disease in Tianjin Institute of Luweisuozhang, asked her to introduce the latest developments related to hepatitis treatment, prevention, liver cirrhosis with severe complications, such as relevant knowledge.

Reporter: Luyuan Zhang, I heard that you are great deal of research on alcoholic liver disease, can tell us about this situation?

Lu Wei: Alcoholic liver is due to the long-term heavy drinking (alcohol)-induced liver injury in diseases. Over the past decade, with the improvement of living standards and social circle expands, the world’s consumption of alcohol soared, due to drinking alcohol, leading to the incidence of liver also showed a rising trend, has become the invisible killer can not be ignored.

Heavy drinking can cause fatty liver, and even alcoholic liver damage. Alcoholic liver will appear a series of symptoms and signs. Mild alcoholic liver occur, such as bloating, fatigue, liver discomfort, anorexia and other common symptoms. In addition to the above-mentioned symptoms of alcohol and adding to the liver, some patients with fever, leukocytosis (mainly an increase in neutrophils), resembles a bacterial infection and other symptoms, and jaundice, hepatomegaly and tenderness, a small number of spleen enlargement, looking gloomy, ascites, edema, spider angioma and a series of symptoms. Mild fatty liver more asymptomatic, moderate and severe fatty liver can present the above-mentioned symptoms, the small number of patients have low-grade fever, diarrhea, limb numbness, tremor, sexual dysfunction and so on. Alcoholic cirrhosis is a more serious alcohol liver disease. If the above symptoms, should go to hospital for examination, so as not to delay treatment.

Alcohol prevention and treatment of alcoholic liver the most effective measures. The treatment of alcohol liver disease, including abstinence, improved nutrition, treatment of liver injury, prevention and treatment in combination with other liver disease, halting or reversing the progress of liver fibrosis and promote liver regeneration, reduce complications and improve quality of life, end-stage liver disease will have to for liver transplantation.

Recently, Tianjin Institute of liver disease research “glucose-based transferrin clinical diagnosis of alcoholic liver disease,” the subject has passed the expert review, Tianjin Public Health Bureau, to leading domestic level.

Reporter: Tianjin Institute for treatment of hepatitis B liver disease what are the characteristics do?

Lu Wei: hepatitis, cirrhosis and liver cancer among there was not only the disease occurrence and development of a causal relationship, but also three completely different diseases. Got hepatitis B do not panic, the vast majority can be treated, and to cirrhosis, liver cancer and only a few. Moreover, liver transplantation is feasible, survival up to 5-30 years. As long as the face of science, attitude adjustment, active treatment, prevent fatigue, periodic inspection, hepatitis B is completely controlled.

Tianjin Institute of Liver Disease has always been adhering to the patient first, quality first, the purpose of, and adhere to the road of integrating Chinese and Western medicine in order to combine Chinese and Western medicine treatment of chronic hepatitis B as a feature, after the efforts of several generations, the Institute absorption, comparison, conclusion, summarizes the ancient and modern Chinese medicine treatment of liver disease and effective prescriptions, developed a series of eight kinds of liver disease treatment drugs, in clinical use has been well received. Such as hepatitis B-1 can effectively inhibit liver fibrosis, reducing Ⅲ, Ⅳ collagen synthesis, is an effective drug prevention and treatment of liver cirrhosis. Hepatitis granules, hepatitis B No. 3, An beads and so on in different aspects of the liver with a JiangMei, back yellow, and hepatoprotective effects.

We developed a “slow liver capsule” as a new drug for the treatment of chronic hepatitis B in 2000 by the State Drug Administration issued a new drug certificate and production approval, and the successful transfer of pharmaceutical companies have been formally put into operation to produce good economic and social benefits.

Reporter: Are you vomiting blood of patients with liver cirrhosis with portal hypertension have any good methods?

Lu Wei: here I would like to remind patients with chronic liver disease should be routine gastroscopy. Cirrhotic portal hypertension in patients with esophageal and gastric mucosa can be combined lesions, severe esophageal varices can occur, easily lead to variceal bleeding, life-threatening. We esophageal varicose vein ligation and endoscopic sclerotherapy for varicose veins of the gastric treatment with injection of tissue glue is completely treatable and prevent upper gastrointestinal bleeding, and thus improve the patient’s quality of life.

Hepatitis B prevention and control "winter march"

Posted on November 4th, 2009 in Folk Health Tips, liver | 1 Comment »

Into the winter, with the body’s own immune function decline in the number of meetings and meals increased significantly, infected with significantly increased risk of hepatitis. It is reported that various types of infectious diseases in the global incidence figures and the number of deaths in both the first row of hepatitis, suggesting that hepatitis B is currently the biggest threat to human health, “killer.” In the hepatitis diseases, hepatitis B patients with the majority.

Prevention of hepatitis B

Winter is indeed a peak transmission of hepatitis B prevention is the key source of infection of hepatitis B control, should pay more attention to their daily lives, such as: medical treatment, injections, acupuncture, tooth extraction and surgical and other medical practices, which should go to regular hospitals. Acceptance of tattoos, Wen-mei, playing ear eyes, and so has the damage done to make eyes the beauty of sexual behavior, pay attention to whether the equipment used strictly disinfected.

Interrupt mother to child transmission of hepatitis B is to control the key. Of hepatitis B virus infection and most of the beginning from early childhood, primarily through mother to child transmission, this approach for the treatment of infections is an extremely unfavorable factors, but also in the spread of hepatitis B in an important factor, and children infected with there will be developed into a variety of post-hepatitis B liver disease may be, most will develop chronic hepatitis, in which there will be nearly half of patients will develop cirrhosis of the liver, and for those infected adults, only about 5%% people will develop into chronic hepatitis, cirrhosis of the liver of patients account for only about two into shows that children infected with hepatitis B virus is more difficult to treat. Therefore, prevention of early childhood prevention and treatment of hepatitis B infection is part of the key.

Is not susceptible in vivo protective antibodies of hepatitis B who should particularly pay attention to these populations could be taken to hepatitis B vaccination approach to be protected.

Farewell Mistakes

Because most people, and pathology of hepatitis B virus transmission is not very understanding, so in many respects to the hepatitis B have a misunderstanding and misperceptions. Understanding of these improper Professor Huang has done some explanation.

Hepatitis B virus does not spread in the air, work, conversation, eating together will not be infected, but the saliva of virus carriers may contain viruses, should be used chopsticks, eating.

Hepatitis B patients can contact with others, as long as daily necessities, with others, separated from hepatitis B infection would not be to others. Hepatitis B surface antigen carriers can be a normal school, work, and live like normal people.

Of hepatitis B virus carriers can be married, but the marriage must be detected in blood of hepatitis B antigen-antibody system, sex life must be controlled to avoid alcohol and fatigue. Within 24 hours after birth to be injected with hepatitis B vaccine.

Adults should vaccination, hepatitis B virus infection in high-risk status of those susceptible to hepatitis B should be vaccinated with hepatitis B vaccine. These mainly include: newborns, infants and preschool children, medical personnel, and hepatitis B patients and virus carriers in close contact with persons.

Daily nursed back to health

Currently, hepatitis B treatment of multiple use of combination therapy, that is, rest, nutrition, mainly medication complementary treatments. Since most home-based treatment in patients with hepatitis convalescence, so daily life of the hepatitis B nursed back to health is also important.

As the saying goes “two-thirds rule, raising seven points,” a rest for the hepatitis B patients is very important. The human body when standing in the bed with the liver blood flow significantly different from supine can reduce the load of the liver and increase liver blood flow.

In the recovery phase, rest principles are: static and dynamic combination of appropriate physical activity. Can be outdoors walking, sunbathing, tai chi and so on. Amount of exercise should be gradually increased, but not fatigue. Patients should maintain more than 10 hours a day of rest, meal and bed rest should in principle be half an hour to 1 hour.

Easily infected with hepatitis B risk behavior!

Posted on October 28th, 2009 in liver | No Comments »

As we all know, blood transmission is the most important means of hepatitis B infection. Here are infected with hepatitis B several possible actions:

1, with hepatitis B virus has been contaminated needle punching tattooing or body, such as wearing earrings.

If the needle to the front of a person used, but in front of that person happens to be the hepatitis B virus carriers, some after the use of small, irregular medical clinic, or cosmetic surgery to have no regular disinfection, when used with a needle to the next When a person with the virus can be brought into the body of the next person.

Small, one has a Toutongnaore, my mother dragged us to the squalid village to a small clinic acupuncture, then where do not know what disinfection sterilization, infection is not contagious, they saw the mysterious Xixi old Chinese medicine, pins to this person over, take a cotton ball at the pin on the alcohol carelessly wipe, the next person on the You Ji acupuncture, and now think I do not know how many people infected by this acupuncture to the hepatitis virus or other viruses. Fortunately, people are now self-protection consciousness is increasing, the majority of the regular large hospitals are using disposable acupuncture needles had. But I worry that there are many people who rely on the survival Kengmengguaipian continue to harm anyone.

2, with others (with the virus people) shared razors, toothbrushes and other personal items may carry traces of blood.

Razors, toothbrushes, etc. after the use is likely to have residues above the blood, although the negligible amount of blood on the naked eye can not be found, but the virus load is sufficient to infect other people.

3, with people sharing needles, especially intravenous drug users sharing needles, people.

Intravenous drug users sharing needles is not only a mode of transmission of AIDS, but also hepatitis B, hepatitis C virus infection and other chronic way, which is why AIDS patients tend to merge more than a viral infection, often HIV / HCV co-infection, that is, AIDS and C liver virus, or HIV / HBV, namely, AIDS and hepatitis B virus infection.

4, unsafe sex or multiple sexual partners.

Sexual intercourse with infected person must take a good condom, only then possible to avoid infection. Condoms can protect you from HIV infection, but also can protect you from hepatitis B virus and other sexually transmitted infections.

Therefore, in order of their health, in addition to hepatitis B vaccine injections, the daily life should be easy to avoid infected hepatitis B virus behavior.

Hepatitis B is liver cancer the biggest killer!

Posted on October 28th, 2009 in liver | No Comments »

Jiucheng liver cancer patients have a history of hepatitis B, hepatitis B who suffered more than other people suffering from liver cancer risk of up to 10.7 times, hepatitis B virus carrying the risk of people suffering from liver cancer is a healthy 6.37 times the population! Why is hepatitis B the virus is apt to cause liver cancer? recently with “viral hepatitis and hepatocellular carcinoma in Asia,” as the theme of the 17th annual meeting of Asia-Pacific liver disease, China, South Korea, Japan and Australia, the Asia-Pacific region a number of liver disease prevention and control experts and scholars opened this “mystery.”

Patients: Treatment of non-standardized liver cancer hepatitis B changed

A seven-point knowledge about hepatitis B HBeAg

51-year-old Mr. Zhang Huan Yigan for 12 years, long-term use of certain drugs, he happened resistance, resulting in a rebound condition. Most recently, he because the company’s business continuity travel, entertainment, feeling tired, liver pain, hastened to the hospital for examination, the doctor says with resignation that has been advanced liver cancer, missed the best time of treatment … … It is understood that, like this case is not uncommon, because the treatment was not standardized, combined liver and neglect their own health, many of hepatitis B patients unknowingly “hit”, hepatitis B become liver cancer, died in the tragedy of the young elite frequent.

Experts say that 90% of liver cancer patients have a history of hepatitis B, hepatitis B virus persistent infection is the main reason for liver cancer. These patients have the following roughly the same performance: Laboratory examination of “HBeAg” or “Xiao Sanyang,” liver function was normal; liver cancer before the disease was found hiding, no obvious symptoms, not even any signs of liver discomfort … … this performance to the patient both struck an urgent alarm: hepatitis B patients to the hospital in time if not standard treatment, may be just one step away from liver cancer away!

Expert: many kinds of drugs should be chosen carefully

“Scientific and standardized treatment is effective in preventing hepatitis B into the key to liver cancer. Hepatitis B need individual therapy, medication, doctors also need to adjust anti-viral therapy.” At the 17th Asia-Pacific Liver Diseases annual meeting, experts said, has been developed out of anti-HBV drugs, has formed a nucleoside (acid) analogues, long-acting interferon in two major categories of drugs to choose from. Recommendation: Medical: Hepatitis B treatment “road map”

Types of drugs increase in the face of the situation, experts believe that patient selection should be cautious, 2007 edition of “Hepatitis B Prevention Guide” is an international art in the fields on the treatment of chronic hepatitis B diagnosis and treatment of regulatory guidance documents, with a high reference value. “Guide” recommends that, for nucleoside naive patients, treatment is started at a preferred anti-virus capability, low rates of drug resistance, and shall ensure compliance of medication, thereby reducing the incidence of drug resistance. Choose from based on the best evidence-based medicine supported by evidence, taking into account also the burden of drug prices and cost factors, differences in the way (such as medical insurance, at their own expense, etc.).

Well-known liver expert, Shanghai Huashan Hospital, Professor Xin-Hua Weng pointed to the need to recognize is that “If you want anti-virus capability, but also to take convenience, drug resistance rate is low, toxic side effects and the price is very cheap, such an ideal drug , and now there is no market. ”

Reminder: Hepatitis B liver incentive to become open to the public

If you are infected with hepatitis B virus, or a doctor declared that you are a hepatitis B patients, we must bear in mind the following 4 points away from the risk factors, in order to stay away from liver cancer invasion: 1. Drinking. The long-term drinking of the hepatitis B surface antigen-positive people can promote the occurrence of liver cirrhosis or liver cancer; 2. To eat rotten oil. Well-worn animal and plant oils are toxic and may cause cancer; 3. To eat moldy food. When they find food, oil, dairy products contaminated with mold is prohibited for human consumption; 4. Unchecked. Hepatitis B patients and their families regularly to the hospital for routine examination, periodic review of serum transaminase, six months to once a year, “two pairs of semi-”, do a fetal-fetoprotein, b super-annual inspections. Otherwise, left unchecked, persistent infection of hepatitis B virus replication, inflammation, fibrosis prompted, will inevitably lead to cirrhosis or liver cancer from happening.

Hepatitis B and Flirt-life of "contradictions"

Posted on October 11th, 2009 in liver | No Comments »

The risk of sexual transmission of hepatitis B virus be?

Sex life is an important part of married life, not all patients with liver disease can affect sexual function and sexual life, and only severe hepatitis, cirrhosis, liver damage due to severe loss of compensation and hormonal disorders may cause sexual dysfunction and sexual obstacles of life.

In the HBV-infected blood, saliva, semen. Vaginal secretions, menstrual blood can be detected in HBV, sexually transmitted HBV has long been affirmed and even abroad, to include hepatitis B, “sexually transmitted diseases,” which indicates the importance of sexually transmitted hepatitis.

Some people have been tested on the vagina for sexual intercourse gibbons action treatment, then sperm injection containing HBV of its vagina, the results gibbon infected with HBV. This suggests that sexual intercourse can indeed share the infected HBV. It was observed in the human body, the newlyweds On one side are HBV carriers, the other not, but after marriage, about 10% -20% of the other infected with HBV. There are 52 cases of our newly married young people (of which 30 males and 20 female) in hepatitis B carriers, and married for one year of observation, their spouses were not hepatitis B carriers, not the spouse of HBV infection in married for one year 29% are infected with HBV, a hepatitis B carrier, after analysis, the exclusion of other infections are mainly marital sexual intercourse sexual intercourse infection.

So, sex between husband and wife caused by HBV infection rate of about 10% -30% or so. Some scholars believe that sex between husband and wife HBV infection is not high, we have seen one of the spouses of HBV carriers, and living together 10 years, decades and no instances of infection. The two sides are not necessarily to be infected, as evidenced by the fact that a lot.

HBV infection can lead to abnormal sexual behavior is higher, our survey of some of the sexual promiscuity, they HBV infection rates as high as 39.1%, while the normal group of HBV infection rate was 9.8 percent, a difference very significant. There are prostitutes on the 560 cases of internal investigations, they HBV infection rate was 21.6%, foreign research reports prostitutes in a country in West Africa HBV infection were as high as 58.1% -80. 2%, the results astounding.

Abnormal behavior including homosexuality, their sexual behavior have “mouth – genital,” “mouth – anal,” “genitalia – Anus,” although they have to clean rectum before sexual intercourse, but there are scholars of fiber endoscopy gay intestinal who found that 59% of the human intestinal existence of asymptomatic lesions, which is frequently a result of flushing and anal sex. If a party is a hepatitis B carriers, so that the other very high risk of HBV infection.

The sexual transmission of HBV is certain exists, it is with the following factors:

⑴, the more sexual partners, higher risk of infection.

⑵, HBV infection in vivo viral load the higher the more active viral replication, the greater the risk of infection

⑶, more poor hygiene, the more susceptible to HBV

⑷, abnormal sexual behavior, abnormal sexual risk behaviors for HBV infection

⑸, themselves must be an HBV susceptible, which means that the body does not look HBV antibodies (anti-HBs), it is easy to infection HBV, such as the body to produce antibodies “anti-HBs” will no longer infected with HBV.

In this case, how should patients with liver disease do sex life?

In the acute phase of viral hepatitis due to liver cell damage, tired, decreased libido, so acute hepatitis should prohibit all sexual activity, in order to reduce physical exertion to promote liver cell recovery, otherwise they will be worse.

Hepatitis recovery may be appropriate to their sex life, and without a sense of fatigue as a degree. With chronic hepatitis and cirrhosis patients may lower sexual desire should not be forced sex life; as to achieve clinical cure of acute hepatitis, chronic hepatitis, up to cure the basic standards in a stable condition for more than six months may be sexually active; followed up after clinical cure of acute hepatitis, one year without exception, chronic hepatitis, no abnormalities were observed for 2 years to the task, and can lead a normal sexual life; HBsAg carriers may be too modest sex life, and consciously controlling the frequency of life, but not indulgent.

Moderate frequency of sexual activity is appropriate, but the period of hepatic dysfunction, especially transaminase increased instability or jaundice should be stopped.

Alcohol and fatty liver disease show no obvious symptoms, half of those in liver discomfort, abdominal distension, anorexia, impotence, irregular menstruation, breast abnormalities such as small number of people with mild abnormal liver function, do not have to taboo sex life, In the abnormal liver function should be temporarily forbidden for some time to restore liver function after the resumption of sex life.

Moderate sex life help ease the sexual tension and achieve a high degree of relaxation wholeheartedly, but also contribute to excessive consumption of fat, to reduce the accumulation of fat in the body, but also played the role of diet and lipid-lowering mile.

Hepatitis in patients with sexual health:

1, acute hepatitis period, when the GPT was significantly higher, malaise, jaundice and other symptoms, they should prohibit sexual activity.

2, recovering from acute hepatitis patients, can be controlled to carry out marital sex life, but it should not be too frequent, and time should not be too long, to the next day without a sense of fatigue degree.

3, patients with liver cirrhosis due to the impact of disease in general are relatively indifferent to sexuality, this time should not bite the bullet, but should comply with the wishes natural. When the liver under control, the in vivo metabolism of sex hormones have been adjusted and the restoration of normal sexual function can also be improved correspondingly.

4, hepatitis B virus carriers and controls, as there is no need for any psychological burden of sexual life.

How the choice of a number of drug hepatitis B?

Posted on October 11th, 2009 in liver | 1 Comment »

Hepatitis B drug after another, such as hospital preparation, research and medicine, Chinese medicine in the Wan San paste Dan and various kinds of “secret prescription,” dazzled people. Hepatitis B drug in so many should be how to choose? Effect of what?

Efficacy of hepatitis B in accordance with their regular medication can be broadly divided into: general hepatoprotective drugs, Hugan restore liver function drugs, antiviral drugs, immunomodulatory drugs, anti-hepatic fibrosis drugs and proprietary Chinese medicines and other six major categories.

General Liver drugs include a variety of vitamins, the liver was Jian, Glucurolactone etc., applicable to all types of hepatitis and cirrhosis of the liver, but may only play a secondary and indirect effects. These drugs can reduce inflammation of the liver and promote liver regeneration, but not the protagonist of hepatitis B treatment.

Liver restore liver function and the longest study of drugs such drugs, efficacy of the most clear, the most widely used, the price is relatively low, including Hugan JiangMei, Hugan drop yellow and Liver protein metabolism in three types of improvements. They are applicable to various types of hepatitis, cirrhosis of the liver appeared aminotransferase, bilirubin increase or decrease albumin and protein ratio of upside-down, etc., which Hugan JiangMei drugs are the most widely used, the most prominent effect of a class of drugs, such as Gomi son, licorice preparations. Clinical hepatitis B patients seen, almost all accompanied by elevated transaminase this phenomenon, under normal circumstances, the use of drugs can be received Hugan JiangMei immediate effect. Although these drugs JiangMei quickly, but not a sudden withdrawal, or transaminase quickly “anti-jump”, a gradual reduction should be to maintain a year or two.

Liver lowering drugs for Huang hepatitis and cirrhosis of the liver in all patients with elevated bilirubin (ie, jaundice), such as western aspartic acid potassium, ursodeoxycholic acid and traditional Chinese medicine Danshen injection agent. One drop Western Huang mainly applicable to accompanied by the characteristics of cholestatic hepatitis, Chinese medicine formulations suitable for various types of high-jaundice cases. Lowering drugs in general should not be used for a long yellow, if the chronic hepatitis B and liver cirrhosis a “residual jaundice” phenomenon, we should not use these drugs can be added with the prescription of Chinese herbal medicine to be adjusted to resolve dialectical.

Liver protein metabolism improving drug, amino acids such as oral capsules, Malotilate and so on, mainly applied to chronic hepatitis (generally moderate), or patients with cirrhosis of the liver to reduce albumin, globulin increased, protein ratio of upside-down, lower the price , efficacy can still be. If the later stage of liver cirrhosis with ascites, hypoalbuminemia, which normally takes input human serum albumin, the price is very expensive. Liver drug treatment to restore liver function in clear and obvious, it is regrettable that they are not cure hepatitis B method, they belong to hepatitis B “symptoms” approach (ie, mitigation of hepatitis B method). They can solve some of hepatitis B surface phenomena, such as mitigation of liver inflammation and promote regeneration, etc., but can not resolve the core issue of hepatitis B – anti-virus treatment.

Antiviral drugs, these drugs for mild to moderate chronic hepatitis, early cirrhosis patients, the main indicators of viral replication (e antigen, hepatitis B virus deoxyribonucleic acid)-positive persons are not generally suitable for the treatment of people living with HIV, severe hepatitis and in patients with advanced liver cirrhosis. Hepatitis B antiviral therapy is the treatment of hepatitis B core and key element is the difficulty where the treatment of hepatitis B, it is a “hard bone”, has yet to “bite” down. Treatment of hepatitis B in China at different times have different “main” drugs, such as the western interferon, lamivudine and traditional Chinese medicine Ganyanlin so on, but the vast majority of anti-viral medicine is a “flash in the pan,” poor efficacy. The 20th century, 90 years, interferon has been solemnly recommend to the nation, at that time was regarded as hepatitis B nemesis, popular for nearly 6-7 years, but due to unsatisfactory efficacy (racial differences, side effects, are expensive and other factors it does not suitable for Chinese people), but also gradually on the decline, replaced by the lamivudine, which is the latest antiviral drugs.

Compared to other western medicine, the lamivudine has many advantages, such as relatively cheap, and side effects, mouth eyes convenient, curb the virus quickly, for the hepatitis B virus DNA (HBV-DNA) negative rate of up to 90 %, and for hepatitis B virus e antigen (HBeAg) of the negative conversion rate was more than 40% and so on and therefore I was all the rage. However, lamivudine is not a magic pill, it does not completely solve the problem of hepatitis B, such as after stopping the “rebound,” within the foreseeable future course of treatment, the virus under drug pressure variation, long-term efficacy is inconclusive and so on . Lamivudine treatment of hepatitis B is also a milestone in the journey, but by no means the end of the treatment of hepatitis B. Many types of antiviral drugs, traditional Chinese medicine, its advantages are cheap, side effects and so on, but Western medicine is relatively speaking, the effectiveness of anti-virus is not enough, the mechanism is not clear, therefore, difficult to solely responsible for hepatitis B “main role.”

Immunomodulatory drugs, including two types of immune enhancer and immune inhibitors. Immunostimulants can enhance cellular immune function and induce endogenous interferon production, the promotion of hepatitis B virus antigen was negative indicators. In addition, some traditional Chinese medicines have their effect. Objectively speaking, preparation is still a hepatitis B immunization adjuvant therapy, but it was too expensive adjuvant therapy, the immune enhancer premium is very high, high level has been more than antiviral drugs, which makes a little “forest for the trees” feeling. Immunosuppressive agents can be used to cholestatic hepatitis, autoimmune hepatitis and severe hepatitis, but the effect is not accurate, anti-viral effect is paradoxical, therefore not worth advocating.